Friday, May 29, 2015

Regarding Hyperkalemia

A 42 year old male had an ankle strain 8 days back for which he was give Diclofenac sodium 50mg Bid. He presented to his GP with complaints of generalized weakness, his baseline workup was all normal except his serum potassium levels which was 5.9 .
What is the path-o-physiology of the drug most likely causing his Hyperkalemia ?
1) Diclofenac contains potassium
2) Diclofenac causes decreased cellular uptake of potassium
3) It induces a state of relative hyporenemic Hypoaldosteronism
4 ) Inhibits Na-Kt ATP ase pump
5) It does not cause hyperkalemia


ANSWER)
3) It induces a state of relative hyporenemic Hypoaldosteronism

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